Product Development & Supply (Pharmaceuticals R&D)

What’s this area all about?

Product Development & Supply progresses the development of new drug products from discovery through clinical trials and registration to the factory and beyond.  We turn the substance with the pharmacological activity into a high-quality formulation or device that patients and volunteers in clinical trials can take or use. We are responsible for the design, development and industrialisation of medicines (e.g. tablets, capsules, vials, inhalers and suspensions) that meet the needs of the patient. We manage R&D supply chains to ensure the right experimental medicines or discovery research compounds (chemical and biological) get to the right place at the right time to meet the needs of clinical trial volunteers and scientists respectively. Our science, engineering and supply chain management activities are critical functions that enable GSK to register and launch three to five new medicines each year.

What is this career like?

3 years
3 rotations

You’ll be a full-time, permanent employee enjoying the same competitive salary and benefits as other new starters. In addition, you’ll take on three rotations over three years at the start of your career with GSK. The three rotations will give you technical capabilities across three distinct areas of the product development process, supply chain management and allied business areas. Throughout these years, you will have numerous opportunities to meet with other graduates for training, and networking events. You will undertake a number of core training and personal development courses.

You’ll have the benefit of improving your technical skills while gaining valuable leadership training through a combination of mentoring, classroom sessions and on-the-job training. This experience will equip you to become a leader of the future and will provide you with a solid foundation for a variety of science careers within the pharmaceutical industry.

You will choose one of the following roles:

Automation Engineering 

This role is UK-based (at our R&D sites in Hertfordshire). As an automation engineer at GSK, you will:

  • Learn to use instrumentation, control and manufacturing systems including Delta V, Syncade, Allen Bradley SCADA, Honeywell Building Automation System, and utility PLCs.
  • Lead the conceptual and detailed design of such systems
  • Interface with users, peers, and management to analyse, derive and capture requirements. Lead a team of external resources to deliver platform components to meet the requirements and realise business value.
  • Identify potential improvement projects and support the business case for investment to management.
  • Define a detailed plan to complete approved projects on schedule and within budget.
  • Manage vendors and consultants to ensure that contracts meet scope and budget.
  • Work with other plant operations, engineering and product introduction teams to implement and maintain automation systems, execute projects and communicate the status effectively.
  • Develop and optimise operation and maintenance procedures as well as training programmes for manufacturing systems.
  • Support the development of validation documentation and implement validation plans for instrumentation and control systems.
  • Maintain and document all cGMP equipment / system modifications and upgrades through approved change control methods.
  • Support on-time completion of quality investigations, corrective actions and preventative actions as required.

In this role, you are the technical expert and leader for all instrumentation and control systems that support the pilot plant operations on site.  The role in the R&D supply chain, Core Technologies Automation team, will help drive and lead projects, truly owning them. You will quickly work out what needs to be done, who needs to be connected, and execute the work with top tier compliance and efficiency. The role will support delivery of the strategy for the reliability, maintenance, performance improvement and compliance of the automation infrastructure for the primary and secondary clinical manufacturing facilities and equipment.

If you have, or expect to obtain in 2017, a minimum of a BA or BSc in computer science, data analytics, engineering (mechanical, electrical, industrial, or chemical) or a closely related discipline where you used computer programming to solve challenging scientific or technical problems, please see the UK page to apply for this role.

Applied Mechanical / Biomedical Engineering (Devices)

This role is UK-based. As an applied mechanical / biomedical engineer (devices) at GSK, you will:

  • Contribute to detailed review of different technologies and device designs to identify potential strengths / weaknesses / opportunities / threats.
  • Build mathematical models using state-of-the-art Computer Aided Engineering tools to understand the operating space, within which a technology and / or device design will operate.
  • Effectively communicate your observations and design remediation ideas based upon your mathematical models.
  • Design, develop and execute test protocols to validate your mathematical models and design remediation ideas to guide product development.
  • Demonstrate an understanding of the literature in your area of technical competency.
  • Actively communicate promising ideas / technologies.
  • Develop a working understanding of the product development process so that you can effectively operate in the broader matrix team.
  • Interact with suppliers, peers and / or formulation scientists to support ongoing projects in order to develop robust, differentiated patient-centric medicines. 

If you have, or expect to obtain in 2017, a Masters (2:1 or better) in mechanical engineering, applied mechanical engineering, biomedical engineering, applied physics or a related subject, please see the UK page to apply for this role.

Process Chemistry

This role is UK-based. As a process chemist at GSK, you will:

  • Play a significant role in the discovery and development of new chemical processes to synthesise drug substances.
  • Use your skills and knowledge in organic chemistry to design and execute experimental work to support the delivery of new synthetic routes and robust manufacturing processes for novel target molecules.
  • Carry out laboratory work to high standards of safety and quality and actively communicate results and progress to your team.
  • Solve complex problems using scientific and technical expertise in order to progress the development of new drug products.
  • Support technology transfer of manufacturing processes for drug substances to GSK and / or third party sites of manufacture.
  • Continue to develop and maintain a high level of relevant scientific and technical expertise in the area of synthetic organic chemistry, including developing a detailed understanding of the requirements of late phase product development such as statistical and first principles modelling.
  • Liaise with key customers in other disciplines across the business in order to deliver product development projects.

If you have, or expect to obtain in 2017, a Bachelors or Masters (2.1 or better) in chemistry, please see the UK page to apply for this role.

Informatics

This role is US-based. As an informatics expert at GSK, you will:

  • Lead the definition and delivery (including implementation and change management) of our data science and informatics solutions across a number of R&D departments.
  • Provide expert technical input and support on data science and informatics to a number of R&D departments.
  • Act as a ‘voice of the customer’ for a number of R&D departments by keeping up-to-date with their challenges and requirements regarding product data and knowledge.
  • Work closely with partners in manufacturing operations towards the vision of a continuum of data, information and knowledge across the product lifecycle.
  • Stay updated on new developments on the cutting edge of computer science, data science and informatics, bringing in those that have the potential to transform the way we operate.
  • Ensure the sustainability of our data science and informatics solutions through the definition and delivery of business processes and guidance material.

If you have, or expect to obtain in 207, a Masters (3.0 GPA or better) or PhD in a STEM subject, computer science, or informatics, where programming was used to solve challenging scientific or technical problems, and you have coursework or research experience relating to the management and / or use of real-world data (e.g. development of algorithms or predictive models, please see the US page to apply for this role.

BioAssets Science

This role is US-based. As a BioAssets scientist at GSK, you will:

  • Develop and implement laboratory processes and technology that support the modernisation of drug discovery, especially in the areas of phenotypic / patient cell-based screening and embed these in the biological sample management capability portfolio.
  • Develop a deep understanding of the BioAssets discovery sample management operation and how it supports drug discovery.
  • Develop a working understanding of the drug discovery process so that you can effectively operate in the broader matrix team.
  • Provide leadership and contribute to detailed review of different technologies to identify key applications / design / process / risks / weaknesses / opportunities / threats.
  • Perform laboratory experiments and processes to test and implement new biological materials for discovery (e.g. differentiating iPS, automating cell culture processes, automated cell separation, culturing cells from primary tissue samples).
  • Develop and maintain current awareness of developing trends in the use of disease-state, primary or engineered biological materials and automation in drug discovery by journal review, presentations, publications and other external networking.
  • Contribute to defining strategies and plans to continually improve discovery biological sample support capability.
  • Provide input to budget decisions, recommends capital purchases of software and equipment required to support modernisation.

If you have, or expect to obtain in 2017, a PhD or Masters (3.0 GPA or better) in biology, biochemistry, drug discovery or a related field, please see the US page to apply for this role.

Formulation Science

This role is US-based. As a formulation scientist at GSK, you will:

  • Develop and conduct test protocols to determine the performance of long-acting injectable technologies.
  • Interpret and use PK-PD and other in vivo or in vitro data to create a model to predict and optimise drug delivery from prototype long-acting injectable formulations.
  • Use this model to assess the potential for optimisation of drug delivery through long-acting injectables demonstrating understanding of the formulation, processing and design of the technology.
  • Demonstrate innovative and independent problem-solving capability when required, with balanced consideration of technical limitations.
  • Demonstrate competence in the areas of processing, integrating and presenting datasets to inform key decision makers.
  • Work with project teams to develop and supply materials for pre-clinical and human testing.
  • Demonstrate an understanding of the literature in your area of technical competency.
  • Actively communicate promising ideas / technologies
  • Contribute to detailed reviews of different technologies to identify key applications / design / process / risks / weaknesses / opportunities / threats.
  • Develop a working understanding of the product development process so that you can effectively operate in the broader matrix team.
  • Prepare development reports and participate in preparing regulatory documents.

If you have, or expect to obtain in 2017, a PhD in pharmaceutical, bio or chemical sciences or chemical or biomedical  engineering  with an emphasis on  the development of injectable formulations and in particular long acting parenterals, please see the US page to apply for this role.

What will I learn?

Part of a vibrant, global scientific community in the pharmaceutical industry, you’ll work in teams that combine a mix of disciplines. You’ll contribute to multi-disciplinary teams that deliver consistent quality in drug substance and drug product. You’ll never be far from an expert who can help you to learn, grow and contribute to our business. You’ll also receive extensive leadership training, coaching and mentoring to equip you to become a technical leader of the future.

Where can I work?

This career path is based in our sites in Philadelphia (for US staff) and Hertfordshire (for UK staff). 

What’s expected of me?

We’ll expect you to get involved in delivering technical projects and prioritising a variety of tasks effectively in support of the drug development process. You’ll need to build working relationships with people across the GSK organisation. To be successful you will need to develop highly effective communication and listening skills, new technical capabilities and knowledge.

What do I need to succeed?

The degree requirements depend on the role (see the country links below) but you’ll need to be ambitious and self-motivated. You'll need the ability to interpret information and a passion for developing medicines. We’re looking for proactive graduates who can quickly build a rapport with a wide range of people. It’s also important that you can adapt to change and keep focused when the pressure is on. While you’ll have the drive and confidence to trust your own judgement, you’ll also be a real team player who actively collaborates with others. In addition, you’ll need an analytical mind, a talent for multi-tasking and the ability to influence others. 

Available Locations